SBT-272 improves TDP-43 pathology in ALS upper motor neurons by modulating mitochondrial integrity, motility, and function

SBT-272 improves TDP-43 pathology in ALS upper motor neurons by modulating mitochondrial integrity, motility, and function

Mitochondrial defects are one of the common underlying causes of neuronal vulnerability in neurodegenerative diseases, such as amyotrophic lateral sclerosis (ALS), and TDP-43 pathology is the most commonly observed proteinopathy. Disrupted inner mitochondrial membrane (IMM) reported in the upper mot...

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Bibliographic Details
Main Authors: Mukesh Gautam, Barış Genç, Benjamin Helmold, Angela Ahrens, Janis Kuka, Marina Makrecka-Kuka, Aksu Günay, Nuran Koçak, Izaak R. Aguilar-Wickings, Dennis Keefe, Guozhu Zheng, Suchitra Swaminathan, Martin Redmon, Hatim A. Zariwala, P. Hande Özdinler
Format: Article
Language:English
Published: Elsevier 2023-03-01
Series:Neurobiology of Disease
Subjects:
TDP-43
Motor neuron disease
SBT-272
Cardiolipin
ATP
Electron transport chain
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996123000360

Internet

http://www.sciencedirect.com/science/article/pii/S0969996123000360

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