NDRG2 Expression in Breast Cancer Cells Downregulates PD-L1 Expression and Restores T Cell Proliferation in Tumor-Coculture

NDRG2 Expression in Breast Cancer Cells Downregulates PD-L1 Expression and Restores T Cell Proliferation in Tumor-Coculture

(1) Background: The aim of the present study was to evaluate the effect of NDRG2 expression in regulating PD-L1 or PD-L2 on malignant breast cancer cells. (2) Methods: Overexpression and knockdown of the NDRG2 gene in human and mouse cancer cells were applied and quantitative real-time PCR and Weste...

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Bibliographic Details
Main Authors: Aram Lee, Soyoung Lim, Juyeong Oh, Jihyun Lim, Young Yang, Myeong-Sok Lee, Jong-Seok Lim
Format: Article
Language:English
Published: MDPI AG 2021-12-01
Series:Cancers
Subjects:
immune checkpoint
PD-L1
NDRG2
breast cancer
T cell proliferation
TCGA data
Online Access:https://www.mdpi.com/2072-6694/13/23/6112

Internet

https://www.mdpi.com/2072-6694/13/23/6112

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