A method for the analysis of the oligomerization profile of the Huntington’s disease-associated, aggregation-prone mutant huntingtin protein by isopycnic ultracentrifugation

A method for the analysis of the oligomerization profile of the Huntington’s disease-associated, aggregation-prone mutant huntingtin protein by isopycnic ultracentrifugation

Conformational diseases, such as Alzheimer’s, Parkinson’s and Huntington’s diseases as well as ataxias and fronto-temporal disorders, are part of common class of neurological disorders characterised by the aggregation and progressive accumulation of mutant proteins which display aberrant conformatio...

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Bibliographic Details
Main Authors: Raffaella Bonavita, Rosaria Di Martino, Giuseppe Cortone, Antonello Prodomo, Mariagrazia Di Gennaro, Gianluca Scerra, Valentino Panico, Silvia Nuzzo, Marco Salvatore, Sarah V. Williams, Fulvia Vitale, Maria Gabriella Caporaso, Massimo D’Agostino, Francesca M. Pisani, Angeleen Fleming, Maurizio Renna
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-06-01
Series:Frontiers in Molecular Biosciences
Subjects:
protein oligomerization and aggregation
sedimentation profile
cell fractionation
differential ultracentrifugation
Huntington’s disease, HTT
Online Access:https://www.frontiersin.org/articles/10.3389/fmolb.2024.1420691/full

Internet

https://www.frontiersin.org/articles/10.3389/fmolb.2024.1420691/full

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