Vildagliptin restores cognitive function and mitigates hippocampal neuronal apoptosis in cisplatin-induced chemo-brain: Imperative roles of AMPK/Akt/CREB/ BDNF signaling cascades

Vildagliptin restores cognitive function and mitigates hippocampal neuronal apoptosis in cisplatin-induced chemo-brain: Imperative roles of AMPK/Akt/CREB/ BDNF signaling cascades

Cisplatin (CP) is a broad-spectrum antineoplastic agent used to treat many human cancers. Nonetheless, most patients receiving CP suffer from cognitive deficits, a phenomenon termed ''chemo-brain''. Recently, vildagliptin (Vilda), a DPP-4 inhibitor, has demonstrated promising neu...

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Bibliographic Details
Main Authors: Abdulla M.A. Mahmoud, Eman M. Mantawy, Sara A. Wahdan, Ramy M. Ammar, Ebtehal El-Demerdash
Format: Article
Language:English
Published: Elsevier 2023-03-01
Series:Biomedicine & Pharmacotherapy
Subjects:
Cisplatin
Vildagliptin
Cognitive function
Chemo brain
AMPK/Akt/CREB
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332223000264

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http://www.sciencedirect.com/science/article/pii/S0753332223000264

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