Novel mechanistic study of HDAC6 regulation of rheumatoid arthritis via CMA: exploring potential therapeutic targets

Novel mechanistic study of HDAC6 regulation of rheumatoid arthritis via CMA: exploring potential therapeutic targets

Objective:Rheumatoid arthritis (RA) is a systemic autoimmune disease. Its pathogenesis has not yet been clarified, so it is urgent to explore therapeutic targets. Here, we clarified the role of HDAC6 in the mechanism of action of RA through mediating chaperone-mediated autophagy (CMA) to provide a c...

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Bibliographic Details
Main Authors: Duoduo Lin, Weipeng Lai, Ningning Zheng, Hongbin Luo, Xiaole Chen, Wenzhong Que, Nanwen Zhang
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-03-01
Series:Frontiers in Pharmacology
Subjects:
rheumatoid arthritis
histone deacetylase 6
heat shock protein
molecular chaperone autophagy
therapeutic target
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2024.1383663/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2024.1383663/full

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