Novel mechanistic study of HDAC6 regulation of rheumatoid arthritis via CMA: exploring potential therapeutic targets

Novel mechanistic study of HDAC6 regulation of rheumatoid arthritis via CMA: exploring potential therapeutic targets

Objective:Rheumatoid arthritis (RA) is a systemic autoimmune disease. Its pathogenesis has not yet been clarified, so it is urgent to explore therapeutic targets. Here, we clarified the role of HDAC6 in the mechanism of action of RA through mediating chaperone-mediated autophagy (CMA) to provide a c...

Full description

Bibliographic Details
Main Authors:	Duoduo Lin, Weipeng Lai, Ningning Zheng, Hongbin Luo, Xiaole Chen, Wenzhong Que, Nanwen Zhang
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2024-03-01
Series:	Frontiers in Pharmacology
Subjects:	rheumatoid arthritis histone deacetylase 6 heat shock protein molecular chaperone autophagy therapeutic target
Online Access:	https://www.frontiersin.org/articles/10.3389/fphar.2024.1383663/full

Similar Items

Attenuation of Rheumatoid Inflammation by Sodium Butyrate Through Reciprocal Targeting of HDAC2 in Osteoclasts and HDAC8 in T Cells
by: Da Som Kim, et al.
Published: (2018-07-01)

Impact of HDAC Inhibitors on Protein Quality Control Systems: Consequences for Precision Medicine in Malignant Disease
by: Linda Anna Michelle Kulka, et al.
Published: (2020-06-01)

The Role of HDACs as Leukemia Therapy Targets using HDI
by: Ahmad Ahmadzadeh, et al.
Published: (2016-02-01)

Small Molecules Targeting HATs, HDACs, and BRDs in Cancer Therapy
by: Donglu Wu, et al.
Published: (2020-11-01)

Therapeutic effect of a novel histone deacetylase 6 inhibitor, CKD-L, on collagen-induced arthritis in vivo and regulatory T cells in rheumatoid arthritis in vitro
by: Bo Ram Oh, et al.
Published: (2017-07-01)

HAT- and HDAC-Targeted Protein Acetylation in the Occurrence and Treatment of Epilepsy
by: Jie Wang, et al.
Published: (2022-12-01)

Anticancer Therapy with HDAC Inhibitors: Mechanism-Based Combination Strategies and Future Perspectives
by: Robert Jenke, et al.
Published: (2021-02-01)

Long Non-Coding RNA NR-133666 Promotes the Proliferation and Migration of Fibroblast-Like Synoviocytes Through Regulating the miR-133c/MAPK1 Axis
by: Nanwen Zhang, et al.
Published: (2022-04-01)

Inhibiting Histone Deacetylase 2 (HDAC2) Promotes Functional Recovery From Stroke
by: Ying Tang, et al.
Published: (2017-10-01)

The Emerging Role of HDACs: Pathology and Therapeutic Targets in Diabetes Mellitus
by: Saikat Dewanjee, et al.
Published: (2021-05-01)

The Importance of the “Time Factor” for the Evaluation of Inhibition Mechanisms: The Case of Selected HDAC6 Inhibitors
by: Edoardo Cellupica, et al.
Published: (2023-07-01)

Metabolism, HDACs, and HDAC Inhibitors: A Systems Biology Perspective
by: Jacob King, et al.
Published: (2021-11-01)

HDAC3 and HDAC8 are required for cilia assembly and elongation
by: Seon-ah Park, et al.
Published: (2019-08-01)

The role of HDAC6 in enhancing macrophage autophagy via the autophagolysosomal pathway to alleviate legionella pneumophila-induced pneumonia
by: Minjia Chen, et al.
Published: (2024-12-01)

TMP269, a small molecule inhibitor of class IIa HDAC, suppresses RABV replication in vitro
by: Juanbin Yin, et al.
Published: (2023-12-01)

Current HDAC Inhibitors in Clinical Trials
by: Elisabetta Di Bello, et al.
Published: (2022-05-01)

Synthesis, Antiplasmodial, and Antileukemia Activity of Dihydroartemisinin–HDAC Inhibitor Hybrids as Multitarget Drugs
by: Lukas von Bredow, et al.
Published: (2022-03-01)

Introducing HDAC-Targeting Radiopharmaceuticals for Glioblastoma Imaging and Therapy
by: Liesbeth Everix, et al.
Published: (2023-02-01)

Epigenetic Regulation of Autophagy Beyond the Cytoplasm: A Review
by: Yin Shi, et al.
Published: (2021-06-01)

Effects of novel HDAC inhibitors on urothelial carcinoma cells
by: Aline Kaletsch, et al.
Published: (2018-07-01)

The replication timing program in the hands of two HDACs
by: Kazumasa Yoshida, et al.
Published: (2014-07-01)

Effect of clinically approved HDAC inhibitors on Plasmodium, Leishmania and Schistosoma parasite growth
by: Ming Jang Chua, et al.
Published: (2017-04-01)

Involvement of HDAC1 and HDAC3 in the Pathology of Polyglutamine Disorders: Therapeutic Implications for Selective HDAC1/HDAC3 Inhibitors
by: Elizabeth A. Thomas
Published: (2014-05-01)

The histone deacetylase NlHDAC1 regulates both female and male fertility in the brown planthopper, Nilaparvata lugens
by: Jin-Li Zhang, et al.
Published: (2018-12-01)

Histone Deacetylases and Histone Deacetylase Inhibitors: Molecular Mechanisms of Action in Various Cancers
by: Masumeh Sanaei, et al.
Published: (2019-01-01)

Molecular Determinants of Cancer Therapy Resistance to HDAC Inhibitor-Induced Autophagy
by: Maria Mrakovcic, et al.
Published: (2019-12-01)

Opportunities and Difficulties in the Repurposing of HDAC Inhibitors as Antiparasitic Agents
by: Tapas Kumar Mohapatra, et al.
Published: (2024-01-01)

Regulation of HDAC11 gene expression in early myogenic differentiation
by: Qiao Li, et al.
Published: (2023-08-01)

Clinical Significance of the Histone Deacetylase 2 (HDAC-2) Expression in Human Breast Cancer
by: Nikolaos Garmpis, et al.
Published: (2022-10-01)

Design, synthesis, and biological evaluation of novel histone deacetylase 6 selective inhibitors
by: Tianyi Zhang, et al.
Published: (2022-05-01)

Gestation and breastfeeding in schistosomotic mice differentially alters the expression of histone deacetylases (HDACs) in adult offspring
by: Gabriela Calixto Ribeiro de Holanda, et al.

Epigenetics in Liver Fibrosis: Could HDACs be a Therapeutic Target?
by: Alex Claveria-Cabello, et al.
Published: (2020-10-01)

EphA2- and HDAC-Targeted Combination Therapy in Endometrial Cancer
by: Robiya Joseph, et al.
Published: (2024-01-01)

Anticancer Ruthenium Complexes with HDAC Isoform Selectivity
by: Jasmine M. Cross, et al.
Published: (2020-05-01)

Cell-of-Origin Targeted Drug Repurposing for Triple-Negative and Inflammatory Breast Carcinoma with HDAC and HSP90 Inhibitors Combined with Niclosamide
by: Udayan Bhattacharya, et al.
Published: (2023-01-01)

Induction of histone deacetylases (HDACs) in human abdominal aortic aneurysm: therapeutic potential of HDAC inhibitors
by: María Galán, et al.
Published: (2016-05-01)

Advanced Progress of Histone Deacetylases in Rheumatic Diseases
by: Liu XM, et al.
Published: (2024-02-01)

In silico analysis of maize HDACs with an emphasis on their response to biotic and abiotic stresses
by: Kang Zhang, et al.
Published: (2020-02-01)

Thiết kế, tổng hợp và đánh giá khả năng ức chế enzyme histone deacetylase (HDAC) in silico của một số dẫn xuất tương tự belinostat
by: Nguyễn Cường Quốc, et al.
Published: (2020-06-01)

HDAC Inhibitors for the Therapy of Triple Negative Breast Cancer
by: Cristina Maccallini, et al.
Published: (2022-05-01)