PI3Kδ Sustains Keratinocyte Hyperproliferation and Epithelial Inflammation: Implications for a Topically Druggable Target in Psoriasis

PI3Kδ Sustains Keratinocyte Hyperproliferation and Epithelial Inflammation: Implications for a Topically Druggable Target in Psoriasis

The phosphatidylinositol 3-kinase (PI3K)-dependent signaling pathway is aberrantly activated in psoriatic lesions and contributes to disease pathogenesis. Among PI3Ks enzymes, PI3Kα, β, and δ isoforms are known to bind the p85 regulatory subunit and mediate activation of AKT and other downstream eff...

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Bibliographic Details
Main Authors: Laura Mercurio, Martina Morelli, Claudia Scarponi, Giovanni Luca Scaglione, Sabatino Pallotta, Cristina Albanesi, Stefania Madonna
Format: Article
Language:English
Published: MDPI AG 2021-10-01
Series:Cells
Subjects:
PI3K isoforms
PI3Kδ
AKT
cytokines
psoriasis
hyperproliferation
Online Access:https://www.mdpi.com/2073-4409/10/10/2636

Internet

https://www.mdpi.com/2073-4409/10/10/2636

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