IDO1 facilitates esophageal carcinoma progression by driving the direct binding of NF-κB and CXCL10

Abstract Esophageal carcinoma (EC), one of the most lethal human malignancies, lacks effective targeted therapies. Indoleamine 2,3-dioxygenase 1 (IDO1) plays a key role in a variety of cancers, but its role and mechanism in EC are still unclear. Immunohistochemistry and qRT-PCR were used to analyze...

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Bibliographic Details
Main Authors: Wenjian Yao, Xiaohai Cui, Haodong Peng, Yongkang Zhang, Xiangbo Jia, Sen Wu, Jian Zhao
Format: Article
Language:English
Published: Nature Publishing Group 2023-10-01
Series:Cell Death Discovery
Online Access:https://doi.org/10.1038/s41420-023-01689-3