Three-dimensional DNA nanomachine biosensor coupled with CRISPR Cas12a cascade amplification for ultrasensitive detection of carcinoembryonic antigen

Three-dimensional DNA nanomachine biosensor coupled with CRISPR Cas12a cascade amplification for ultrasensitive detection of carcinoembryonic antigen

Abstract The detection of carcinoembryonic antigen (CEA) holds significant importance in the early diagnosis of cancer. However, current methods are hindered by limited accessibility and specificity. This study proposes a rapid and convenient Cas12a-based assay for the direct detection of CEA in cli...

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Bibliographic Details
Main Authors: Shuo Yao, Yi Liu, Yukun Ding, Xuening Shi, Hang Li, Chao Zhao, Juan Wang
Format: Article
Language:English
Published: BMC 2024-05-01
Series:Journal of Nanobiotechnology
Subjects:
DNA rolling machine
CRISPR-Cas12a
CEA
Cascade amplification
Online Access:https://doi.org/10.1186/s12951-024-02535-z

Internet

https://doi.org/10.1186/s12951-024-02535-z

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