The Predictive Value of MAP2K1/2 Mutations on Efficiency of Immunotherapy in Melanoma

The Predictive Value of MAP2K1/2 Mutations on Efficiency of Immunotherapy in Melanoma

BackgroundMAP2K1/2 genes are mutated in approximately 8% of melanoma patients; however, the impact of MAP2K1/2 gene alterations on the efficiency of immunotherapy has not been clarified. This study focused on the correlation between MAP2K1/2 gene mutations and the treatment response.MethodsSix metas...

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Bibliographic Details
Main Authors: Ting Ye, Jie-Ying Zhang, Xin-Yi Liu, Yu-Han Zhou, Si-Yue Yuan, Meng-Mei Yang, Wen-Zhuan Xie, Chan Gao, Yao-Xu Chen, Meng-Li Huang, Cheng-Zhi Ye, Jing Chen
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-01-01
Series:Frontiers in Immunology
Subjects:
melanoma
CTLA-4 blockade
PD-1 blockade
MAPK pathway
immunotherapy
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.785526/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2021.785526/full

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