Bone morphogenetic protein 7 promotes resistance to immunotherapy

Bone morphogenetic protein 7 promotes resistance to immunotherapy

The mechanisms underlying resistance to immunotherapy are still poorly understood. Here, the authors show that BMP7, a molecule part of the TGF-beta superfamily, suppresses proinflammatory antitumor responses and may represent a target for overcoming resistance to PD1 inhibitors.

Bibliographic Details
Main Authors: Maria Angelica Cortez, Fatemeh Masrorpour, Cristina Ivan, Jie Zhang, Ahmed I. Younes, Yue Lu, Marcos R Estecio, Hampartsoum B. Barsoumian, Hari Menon, Mauricio da Silva Caetano, Rishab Ramapriyan, Jonathan E. Schoenhals, Xiaohong Wang, Ferdinandos Skoulidis, Mark D. Wasley, George Calin, Patrick Hwu, James W. Welsh
Format: Article
Language:English
Published: Nature Portfolio 2020-09-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-020-18617-z

Internet

https://doi.org/10.1038/s41467-020-18617-z

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