In vitro and ex vivo proteomics of Mycobacterium marinum biofilms and the development of biofilm-binding synthetic nanobodies

In vitro and ex vivo proteomics of Mycobacterium marinum biofilms and the development of biofilm-binding synthetic nanobodies

ABSTRACT The antibiotic-tolerant biofilms present in tuberculous granulomas add an additional layer of complexity when treating mycobacterial infections, including tuberculosis (TB). For a more efficient treatment of TB, the biofilm forms of mycobacteria warrant specific attention. Here, we used Myc...

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Bibliographic Details
Main Authors: Milka Marjut Hammarén, Hanna Luukinen, Alina Sillanpää, Kim Remans, Karine Lapouge, Tânia Custódio, Christian Löw, Henna Myllymäki, Toni Montonen, Markus Seeger, Joseph Robertson, Tuula A. Nyman, Kirsi Savijoki, Mataleena Parikka
Format: Article
Language:English
Published: American Society for Microbiology 2023-06-01
Series:mSystems
Subjects:
Mycobacterium
biofilm
surface proteome
synthetic nanobody libraries
nanobody
biofilm-targeted therapy
Online Access:https://journals.asm.org/doi/10.1128/msystems.01073-22

Internet

https://journals.asm.org/doi/10.1128/msystems.01073-22

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