Interplay of p62-mTORC1 and EGFR signaling promotes cisplatin resistance in oral cancer

Interplay of p62-mTORC1 and EGFR signaling promotes cisplatin resistance in oral cancer

Cisplatin resistance poses a major challenge in the treatment of oral squamous cell carcinoma (OSCC). Deeper investigations into the mechanisms underlying this drug resistance is of great importance. Here, we used cellular assays and clinical immunohistochemistry to examine molecular pathways involv...

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Bibliographic Details
Main Authors: Hsiu-Chuan Chang, Cheng-Chieh Yang, Lai-Keng Loi, Chi-Hsun Hung, Cheng-Hsien Wu, Yu-Cheng Lin
Format: Article
Language:English
Published: Elsevier 2024-03-01
Series:Heliyon
Subjects:
OSCC
p62
mTOR
EGFR
Cisplatin resistance
Online Access:http://www.sciencedirect.com/science/article/pii/S2405844024044372

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http://www.sciencedirect.com/science/article/pii/S2405844024044372

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