Intercellular Adhesion-Dependent Cell Survival and ROCK-Regulated Actomyosin-Driven Forces Mediate Self-Formation of a Retinal Organoid

Intercellular Adhesion-Dependent Cell Survival and ROCK-Regulated Actomyosin-Driven Forces Mediate Self-Formation of a Retinal Organoid

In this study we dissected retinal organoid morphogenesis in human embryonic stem cell (hESC)-derived cultures and established a convenient method for isolating large quantities of retinal organoids for modeling human retinal development and disease. Epithelialized cysts were generated via floating...

Full description

Bibliographic Details
Main Authors: Albert Lowe, Raven Harris, Punita Bhansali, Ales Cvekl, Wei Liu
Format: Article
Language:English
Published: Elsevier 2016-05-01
Series:Stem Cell Reports
Subjects:
human embryonic stem cells
differentiation
extracellular matrix
epithelialization
apicobasal cell polarity
retinal progenitor cells
self-organizing organoids
cell adhesion
Rho kinase (ROCK)
actomyosin
cell survival
cell-surface tension
Online Access:http://www.sciencedirect.com/science/article/pii/S2213671116300066

Internet

http://www.sciencedirect.com/science/article/pii/S2213671116300066

Similar Items