Drosophila melanogaster: A new model to study cisplatin-induced neurotoxicity

Platinum-based compounds are widely used and effective chemotherapeutic agents; however, sensory peripheral neuropathy is a dose-limiting and long term side effect for 20–30% of patients. A critical question is whether the mechanisms of cell death underlying clinical efficacy can be separated from t...

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Bibliographic Details
Main Authors: Jewel L. Podratz, Nathan P. Staff, Dara Froemel, Anna Wallner, Florian Wabnig, Allan J. Bieber, Amy Tang, Anthony J. Windebank
Format: Article
Language:English
Published: Elsevier 2011-08-01
Series:Neurobiology of Disease
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996111001173