Zn<sup>2+</sup> Differentially Influences the Neutralisation of Heparins by HRG, Fibrinogen, and Fibronectin

Zn<sup>2+</sup> Differentially Influences the Neutralisation of Heparins by HRG, Fibrinogen, and Fibronectin

For coagulation to be initiated, anticoagulant glycosaminoglycans (GAGs) such as heparins need to be neutralised to allow fibrin clot formation. Platelet activation triggers the release of several proteins that bind GAGs, including histidine-rich glycoprotein (HRG), fibrinogen, and fibronectin. Zn&l...

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Bibliographic Details
Main Authors: Amélie I. S. Sobczak, Ramzi A. Ajjan, Alan J. Stewart
Format: Article
Language:English
Published: MDPI AG 2023-11-01
Series:International Journal of Molecular Sciences
Subjects:
coagulation factors
factor Xa
fibrinogen/fibrin
thrombin
zinc
Online Access:https://www.mdpi.com/1422-0067/24/23/16667

Internet

https://www.mdpi.com/1422-0067/24/23/16667

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