Study of the mechanism of antibacterial action of 1,4-di- and 1,4,5-trisubstituted 1Н-1,2,3-triazoles by molecular modeling

Study of the mechanism of antibacterial action of 1,4-di- and 1,4,5-trisubstituted 1Н-1,2,3-triazoles by molecular modeling

The target for antibacterial action of 1,4-di- and 1,4,5-trisubstituted 1H-1,2,3-triazoles against E. coli ATCC 25922 and S. aureus ATCC 6538 was proposed. Structures of target proteins and investigated triazoles were built using molecular modeling. Binding mechanism was suggested according to condu...

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Bibliographic Details
Main Authors: Cyril M. Verbilo, Alexander V. Zuraev, Yuri V. Grigoriev, Vladislav A. Budevich, Oleg A. Ivashkevich
Format: Article
Language:Belarusian
Published: Belarusian State University 2020-03-01
Series:Журнал Белорусского государственного университета: Химия
Subjects:
molecular modeling
docking
antibacterial activity
e. coli
s. aureus
1н-1,2,3-triazoles
Online Access:https://journals.bsu.by/index.php/chemistry/article/view/1278

Internet

https://journals.bsu.by/index.php/chemistry/article/view/1278

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