Overall survival according to time-of-day of combined immuno-chemotherapy for advanced non-small cell lung cancer: a bicentric bicontinental studyResearch in context

Overall survival according to time-of-day of combined immuno-chemotherapy for advanced non-small cell lung cancer: a bicentric bicontinental studyResearch in context

Summary: Background: Circadian rhythms regulate immune cell activity, influencing responses to vaccines, and immune checkpoint inhibitors (ICIs). Early time-of-day administration (ToDA) of singe-agent ICIs has been associated with improved overall survival (OS) in patients with metastatic “immunoth...

Full description

Bibliographic Details
Main Authors: Zhe Huang, Abdoulaye Karaboué, Liang Zeng, Adrien Lecoeuvre, Lemeng Zhang, Xiao-Mei Li, Haoyue Qin, Gabrielle Danino, Feng Yang, Marie-Sara Malin, Li Deng, Marte Rigal, Hong Liu, Xiang Chen, Qinqin Xu, Lamiae Grimaldi, Thierry Collon, Jing Wang, René Adam, Nong Yang, Boris Duchemann, Yongchang Zhang, Francis Lévi
Format: Article
Language:English
Published: Elsevier 2025-03-01
Series:EBioMedicine
Subjects:
Circadian rhythm
Chronotherapy
Immune checkpoint inhibitors
Time of day of administration
Lung cancer
Immuno-chemotherapy
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396425000519

Internet

http://www.sciencedirect.com/science/article/pii/S2352396425000519

Similar Items