CRISPRi-mediated knock-down of PRDM1/BLIMP1 programs central memory differentiation in ex vivo-expanded human T cells

CRISPRi-mediated knock-down of PRDM1/BLIMP1 programs central memory differentiation in ex vivo-expanded human T cells

Introduction: B lymphocyte-induced maturation protein 1 (BLIMP1) encoded by the positive regulatory domain 1 gene (PRDM1), is a key regulator in T cell differentiation in mouse models. BLIMP1-deficiency results in a lower effector phenotype and a higher memory phenotype. Methods: In this study, we a...

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Bibliographic Details
Main Authors: Mohammad Azadbakht, Ali Sayadmanesh, Naghme Nazer, Amirhossein Ahmadi, Sara Hemmati, Hoda Mohammadzade, Marzieh Ebrahimi, Hossein Baharvand, Babak Khalaj, Mahmoud Reza Aghamaali, Mohsen Basiri
Format: Article
Language:English
Published: Tabriz University of Medical Sciences 2022-07-01
Series:BioImpacts
Subjects:
t cell
prdm1
blimp1
crispr interference
memory t cell
Online Access:https://bi.tbzmed.ac.ir/PDF/bi-12-337.pdf

Internet

https://bi.tbzmed.ac.ir/PDF/bi-12-337.pdf

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