THZ1 targeting CDK7 suppresses c-KIT transcriptional activity in gastrointestinal stromal tumours

THZ1 targeting CDK7 suppresses c-KIT transcriptional activity in gastrointestinal stromal tumours

Abstract Background Gastrointestinal stromal tumours (GISTs) are the most common mesenchymal tumours of the gastrointestinal tract and are characterized by activating mutations of c-KIT or PDGFRa receptor tyrosine kinases (RTKs). Despite the clinical success of tyrosine kinase inhibitors (TKIs), mor...

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Bibliographic Details
Main Authors: Jianyi Sun, Qiang Zhang, Xiangfei Sun, Anwei Xue, Xiaodong Gao, Kuntang Shen
Format: Article
Language:English
Published: BMC 2022-09-01
Series:Cell Communication and Signaling
Subjects:
GIST
CDK7
THZ1
OSR1
Transcription regulation
Online Access:https://doi.org/10.1186/s12964-022-00928-x

Internet

https://doi.org/10.1186/s12964-022-00928-x

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