Discovery of Novel Antitumor Small-Molecule Agent with Dual Action of CDK2/p-RB and MDM2/p53

Discovery of Novel Antitumor Small-Molecule Agent with Dual Action of CDK2/p-RB and MDM2/p53

Cell cycle-dependent kinase 2 (CDK2) is located downstream of CDK4/6 in the cell cycle and regulates cell entry into S-phase by binding to Cyclin E and hyper-phosphorylating Rb. Proto-oncogene murine double minute 2 (MDM2) is a key negative regulator of p53, which is highly expressed in tumors and p...

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Bibliographic Details
Main Authors: Zhaofeng Liu, Yifei Yang, Xiaohui Sun, Runchen Ma, Wenjing Zhang, Wenyan Wang, Gangqiang Yang, Hongbo Wang, Jianzhao Zhang, Yunjie Wang, Jingwei Tian
Format: Article
Language:English
Published: MDPI AG 2024-02-01
Series:Molecules
Subjects:
antitumor drug
CDK2
MDM2
p53
Online Access:https://www.mdpi.com/1420-3049/29/3/725

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https://www.mdpi.com/1420-3049/29/3/725

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