Cell type-specific induction of ferroptosis to boost antitumor immunity

Cell type-specific induction of ferroptosis to boost antitumor immunity

Traditional ferroptosis activators typically suppress antitumor immunity. Our discovery shows that N6F11, a small molecule compound, can selectively induce ferroptosis by targeting TRIM25-mediated GPX4 degradation in cancer cells while sparing immune cells. This breakthrough establishes a safe and e...

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Bibliographic Details
Main Authors: Jiao Liu, Jingbo Li, Rui Kang, Daolin Tang
Format: Article
Language:English
Published: Taylor & Francis Group 2023-12-01
Series:OncoImmunology
Subjects:
Drug discovery
ferroptosis
GPX4
immunotherapy
TRIM25
Online Access:https://www.tandfonline.com/doi/10.1080/2162402X.2023.2282252

Internet

https://www.tandfonline.com/doi/10.1080/2162402X.2023.2282252

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