Precise genetic control of ATOH1 enhances maturation of regenerated hair cells in the mature mouse utricle

Precise genetic control of ATOH1 enhances maturation of regenerated hair cells in the mature mouse utricle

Abstract Vestibular hair cells are mechanoreceptors critical for detecting head position and motion. In mammals, hair cell loss causes vestibular dysfunction as spontaneous regeneration is nearly absent. Constitutive expression of exogenous ATOH1, a hair cell transcription factor, increases hair cel...

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Main Authors: Tian Wang, Tian Yang, Amanda Kedaigle, Gabriela Pregernig, Ryan McCarthy, Ben Holmes, Xudong Wu, Lars Becker, Ning Pan, Kathy So, Leon Chen, Jun He, Ahmad Mahmoudi, Soumya Negi, Monika Kowalczyk, Tyler Gibson, Noah Druckenbrod, Alan G. Cheng, Joseph Burns
Format: Article
Language:English
Published: Nature Portfolio 2024-10-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-024-53153-0

Internet

https://doi.org/10.1038/s41467-024-53153-0

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