Comparative proteomics reveals the mechanism of cyclosporine production and mycelial growth in Tolypocladium inflatum affected by different carbon sources

Comparative proteomics reveals the mechanism of cyclosporine production and mycelial growth in Tolypocladium inflatum affected by different carbon sources

Cyclosporine A (CsA) is a secondary cyclopeptide metabolite produced by Tolypocladium inflatum that is widely used clinically as an immunosuppressant. CsA production and mycelial growth differed when T. inflatum was cultured in different carbon source media. During early fermentation, CsA was prefer...

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Bibliographic Details
Main Authors: Junqi Wang, Meijie Liu, Chengzhi Mao, Sizhu Li, Jiabao Zhou, Yaqin Fan, Lizhong Guo, Hao Yu, Xiuqing Yang
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-12-01
Series:Frontiers in Microbiology
Subjects:
Tolypocladium inflatum
carbon sources
fructose
sucrose
cyclosporine A
mycelium
Online Access:https://www.frontiersin.org/articles/10.3389/fmicb.2023.1259101/full

Internet

https://www.frontiersin.org/articles/10.3389/fmicb.2023.1259101/full

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