Long-Term Cultured Human Glioblastoma Multiforme Cells Demonstrate Increased Radiosensitivity and Senescence-Associated Secretory Phenotype in Response to Irradiation

Long-Term Cultured Human Glioblastoma Multiforme Cells Demonstrate Increased Radiosensitivity and Senescence-Associated Secretory Phenotype in Response to Irradiation

The overall effect of senescence on cancer progression and cancer cell resistance to X-ray radiation (IR) is still not fully understood and remains controversial. How to induce tumor cell senescence and which senescent cell characteristics will ensure the safest therapeutic strategy for cancer treat...

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Bibliographic Details
Main Authors: Lina Alhaddad, Zain Nofal, Margarita Pustovalova, Andreyan N. Osipov, Sergey Leonov
Format: Article
Language:English
Published: MDPI AG 2023-01-01
Series:International Journal of Molecular Sciences
Subjects:
glioblastoma multiforme
multinucleated giant cancer cell
senescent tumor cells (STC)
stress-induced premature senescence (SIPS)
senescence-associated secretory phenotype (SASP)
Online Access:https://www.mdpi.com/1422-0067/24/3/2002

Internet

https://www.mdpi.com/1422-0067/24/3/2002

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