Neurotoxic/Neuroprotective Effects of Clozapine and the Positive Allosteric Modulator of mGluR2 JNJ-46356479 in Human Neuroblastoma Cell Cultures

Neurotoxic/Neuroprotective Effects of Clozapine and the Positive Allosteric Modulator of mGluR2 JNJ-46356479 in Human Neuroblastoma Cell Cultures

Current antipsychotics (APs) effectively control positive psychotic symptoms, mainly by blocking dopamine (DA) D2 receptors, but have little effect on negative and cognitive symptoms. Increased glutamate (GLU) release would trigger neurotoxicity, leading to apoptosis and synaptic pruning, which is i...

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Bibliographic Details
Main Authors: Patricia Gassó, Albert Martínez-Pinteño, Natalia Rodríguez, Santiago Madero, Marta Gómez, Alex G. Segura, Clemente García-Rizo, Constanza Morén, Sergi Mas, Eduard Parellada
Format: Article
Language:English
Published: MDPI AG 2023-01-01
Series:International Journal of Molecular Sciences
Subjects:
JNJ-46356479
positive allosteric modulator
mGluR2
apoptosis
antipsychotic
schizophrenia
Online Access:https://www.mdpi.com/1422-0067/24/3/2054

Internet

https://www.mdpi.com/1422-0067/24/3/2054

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