Recent perspectives on the relations between faecal mutagenicity, genotoxicity and diet
DNA damage is an essential component of the genesis of colonic cancer. Gut microbial products and food components are thought to be principally responsible for the damage that initiates disease progression. Modified Ames tests and Comet assays have been developed for measuring mutagenicity and geno...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2011-03-01
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| Series: | Frontiers in Pharmacology |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fphar.2011.00004/full |
| _version_ | 1818163685614419968 |
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| author | Silvia eGratz R. John eWallace Hani eEl-Nezami Hani eEl-Nezami |
| author_facet | Silvia eGratz R. John eWallace Hani eEl-Nezami Hani eEl-Nezami |
| author_sort | Silvia eGratz |
| collection | DOAJ |
| description | DNA damage is an essential component of the genesis of colonic cancer. Gut microbial products and food components are thought to be principally responsible for the damage that initiates disease progression. Modified Ames tests and Comet assays have been developed for measuring mutagenicity and genotoxicity. Their relevance to oncogenesis remains to be confirmed, as does the relative importance of different mutagenic and genotoxic compounds present in faecal water and the bacteria involved in their metabolism. Dietary intervention studies provide clues to the likely risks of oncogenesis. High-protein diets lead to increases in N-nitroso compounds in faecal water and greater DNA damage as measured by the Comet assay, for example. Other dietary interventions, such as non-digestible carbohydrates and probiotics, may lead to lower faecal genotoxicity. In order to make recommendations to the general public, we must develop a better understanding of how genotoxic compounds are formed in the colon, how accurate the Ames and Comet assays are, and how diet affects genotoxicity. |
| first_indexed | 2024-12-11T16:53:29Z |
| format | Article |
| id | doaj.art-50463daa45ed40788050b6c950a484ff |
| institution | Directory Open Access Journal |
| issn | 1663-9812 |
| language | English |
| last_indexed | 2024-12-11T16:53:29Z |
| publishDate | 2011-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj.art-50463daa45ed40788050b6c950a484ff2022-12-22T00:58:03ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122011-03-01210.3389/fphar.2011.000047472Recent perspectives on the relations between faecal mutagenicity, genotoxicity and dietSilvia eGratz0R. John eWallace1Hani eEl-Nezami2Hani eEl-Nezami3University of AberdeenUniversity of AberdeenUniversity of Hong KongUniversity of Eastern FinlandDNA damage is an essential component of the genesis of colonic cancer. Gut microbial products and food components are thought to be principally responsible for the damage that initiates disease progression. Modified Ames tests and Comet assays have been developed for measuring mutagenicity and genotoxicity. Their relevance to oncogenesis remains to be confirmed, as does the relative importance of different mutagenic and genotoxic compounds present in faecal water and the bacteria involved in their metabolism. Dietary intervention studies provide clues to the likely risks of oncogenesis. High-protein diets lead to increases in N-nitroso compounds in faecal water and greater DNA damage as measured by the Comet assay, for example. Other dietary interventions, such as non-digestible carbohydrates and probiotics, may lead to lower faecal genotoxicity. In order to make recommendations to the general public, we must develop a better understanding of how genotoxic compounds are formed in the colon, how accurate the Ames and Comet assays are, and how diet affects genotoxicity.http://journal.frontiersin.org/Journal/10.3389/fphar.2011.00004/fullColonComet AssayDietDNAAmes testfaeces |
| spellingShingle | Silvia eGratz R. John eWallace Hani eEl-Nezami Hani eEl-Nezami Recent perspectives on the relations between faecal mutagenicity, genotoxicity and diet Frontiers in Pharmacology Colon Comet Assay Diet DNA Ames test faeces |
| title | Recent perspectives on the relations between faecal mutagenicity, genotoxicity and diet |
| title_full | Recent perspectives on the relations between faecal mutagenicity, genotoxicity and diet |
| title_fullStr | Recent perspectives on the relations between faecal mutagenicity, genotoxicity and diet |
| title_full_unstemmed | Recent perspectives on the relations between faecal mutagenicity, genotoxicity and diet |
| title_short | Recent perspectives on the relations between faecal mutagenicity, genotoxicity and diet |
| title_sort | recent perspectives on the relations between faecal mutagenicity genotoxicity and diet |
| topic | Colon Comet Assay Diet DNA Ames test faeces |
| url | http://journal.frontiersin.org/Journal/10.3389/fphar.2011.00004/full |
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