Grignard Reagent Utilization Enables a Practical and Scalable Construction of 3-Substituted 5-Chloro-1,6-naphthyridin-4-one Derivatives

Grignard Reagent Utilization Enables a Practical and Scalable Construction of 3-Substituted 5-Chloro-1,6-naphthyridin-4-one Derivatives

A robust, practical, and scalable approach for the construction of 3-substituted 5-chloro-1,6-naphthyridin-4-one derivatives <b>13</b> via the addition of Grignard reagents to 4-amino-2-chloronicotinonitrile (<b>15</b>) was developed. Starting with various Grignard reagents,...

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Bibliographic Details
Main Authors: Ming-Shu Wang, Yi Gong, Zhi-Cheng Yu, Yan-Guang Tian, Lin-Sheng Zhuo, Wei Huang, Neng-Fang She
Format: Article
Language:English
Published: MDPI AG 2020-12-01
Series:Molecules
Subjects:
1,6-naphthyridine
Grignard reagent
kinase inhibitor
antitumor drug candidate
Online Access:https://www.mdpi.com/1420-3049/25/23/5667

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https://www.mdpi.com/1420-3049/25/23/5667

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