Targeting colorectal cancer cells using AND-gated adaptor RevCAR T-cells

Targeting colorectal cancer cells using AND-gated adaptor RevCAR T-cells

Despite the success of chimeric antigen receptor (CAR) T-cells especially for treating hematological malignancies, critical drawbacks, such as “on-target, off-tumor” toxicities, need to be addressed to improve safety in translating to clinical application. This is especially true, when targeting tum...

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Bibliographic Details
Main Authors: Karla E. G. Soto, Liliana R. Loureiro, Tabea Bartsch, Claudia Arndt, Alexandra Kegler, Nicola Mitwasi, Laura Drewitz, Lydia Hoffmann, Haidy A. Saleh, Eugenia Crespo, Maria Mehnert, Cansu Daglar, Hinrich Abken, Frank Momburg, Michael Bachmann, Anja Feldmann
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-12-01
Series:Frontiers in Immunology
Subjects:
colorectal cancer
CAR T-cells
AND-gate targeting
CEA
EpCAM
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1302354/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2023.1302354/full

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