Design, synthesis, cytotoxicity evaluation and docking studies of 1,2,4-triazine derivatives bearing different arylidene-hydrazinyl moieties as potential mTOR inhibitors

Design, synthesis, cytotoxicity evaluation and docking studies of 1,2,4-triazine derivatives bearing different arylidene-hydrazinyl moieties as potential mTOR inhibitors

Mammalian target of rapamycin (mTOR) is a phosphoinositide 3-kinase-related protein kinase which controls cell growth and is frequently deregulated in many cancers. Therefore, mTOR inhibitors are used as antineoplastic agents for cancer treatment. In this study, 1,2,4-triazine derivatives containing...

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Bibliographic Details
Main Authors: Sara Ranjbar, Najmeh Edraki, Mahsima Khoshneviszadeh, Alireza Foroumadi, Ramin Miri, Mehdi Khoshneviszadeh
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2018-01-01
Series:Research in Pharmaceutical Sciences
Subjects:
cancer; mtor inhibitor; 1
2
4-triazines; docking; mtt
Online Access:http://www.rpsjournal.net/article.asp?issn=1735-5362;year=2018;volume=13;issue=1;spage=1;epage=11;aulast=Ranjbar

Internet

http://www.rpsjournal.net/article.asp?issn=1735-5362;year=2018;volume=13;issue=1;spage=1;epage=11;aulast=Ranjbar

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