SNPs, short tandem repeats, and structural variants are responsible for differential gene expression across C57BL/6 and C57BL/10 substrains

SNPs, short tandem repeats, and structural variants are responsible for differential gene expression across C57BL/6 and C57BL/10 substrains

Summary: Mouse substrains are an invaluable model for understanding disease. We compared C57BL/6J, which is the most commonly used inbred mouse strain, with eight C57BL/6 and five C57BL/10 closely related inbred substrains. Whole-genome sequencing and RNA-sequencing analysis yielded 352,631 SNPs, 10...

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Bibliographic Details
Main Authors: Milad Mortazavi, Yangsu Ren, Shubham Saini, Danny Antaki, Celine L. St. Pierre, April Williams, Abhishek Sohni, Miles F. Wilkinson, Melissa Gymrek, Jonathan Sebat, Abraham A. Palmer
Format: Article
Language:English
Published: Elsevier 2022-03-01
Series:Cell Genomics
Subjects:
C57BL/6
C57BL/10
reduced complexity cross
substrain
mutational processes
gene expression
Online Access:http://www.sciencedirect.com/science/article/pii/S2666979X22000192

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http://www.sciencedirect.com/science/article/pii/S2666979X22000192

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