Genistein inhibits angiogenesis developed during rheumatoid arthritis through the IL-6/JAK2/STAT3/VEGF signalling pathway

Genistein inhibits angiogenesis developed during rheumatoid arthritis through the IL-6/JAK2/STAT3/VEGF signalling pathway

Background: Angiogenesis plays an important role in the development of rheumatoid arthritis (RA), which increases the supply of nutrients, cytokines, and inflammatory cells to the synovial membrane. Genistein (GEN), a soy-derived isoflavone, has been validated that can effectively inhibit the angiog...

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Bibliographic Details
Main Authors: Wen-Xiang Cheng, Huan Huang, Jian-Hai Chen, Tian-Tian Zhang, Guo-Yuan Zhu, Zheng-Tan Zheng, Jie-Tao Lin, Yi-Ping Hu, Yong Zhang, Xue-Ling Bai, Yan Wang, Zhan-Wang Xu, Bing Song, Yi-Ying Mao, Fei Yang, Peng Zhang
Format: Article
Language:English
Published: Elsevier 2020-05-01
Series:Journal of Orthopaedic Translation
Subjects:
Angiogenesis
Genistein
Rheumatoid arthritis
Online Access:http://www.sciencedirect.com/science/article/pii/S2214031X19301901

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http://www.sciencedirect.com/science/article/pii/S2214031X19301901

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