Targeting lysyl-oxidase (LOX) may facilitate intramural periarterial drainage for the treatment of Alzheimer's disease

Targeting lysyl-oxidase (LOX) may facilitate intramural periarterial drainage for the treatment of Alzheimer's disease

Alzheimer's disease is the commonest form of dementia. It is likely that a lack of clearance of amyloid beta (Aβ) results in its accumulation in the parenchyma as Aβ oligomers and insoluble plaques, and within the walls of blood vessels as cerebral amyloid angiopathy (CAA). The drainage of Aβ a...

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Bibliographic Details
Main Authors: Louise Kelly, Matthew Macgregor Sharp, Isabelle Thomas, Christopher Brown, Matthew Schrag, Lissa Ventura Antunes, Elena Solopova, José Martinez-Gonzalez, Cristina Rodríguez, Roxana Octavia Carare
Format: Article
Language:English
Published: Elsevier 2023-01-01
Series:Cerebral Circulation - Cognition and Behavior
Subjects:
Lysyl oxidase
Cerebral amyloid angiopathy
Basement membrane
Dementia
Alzheimer's disease
Amyloid beta
Online Access:http://www.sciencedirect.com/science/article/pii/S2666245023000156

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http://www.sciencedirect.com/science/article/pii/S2666245023000156

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