Alkanediamide-Linked Bisbenzamidines Are Promising Antiparasitic Agents

Alkanediamide-Linked Bisbenzamidines Are Promising Antiparasitic Agents

A series of 15 alkanediamide-linked bisbenzamidines and related analogs was synthesized and tested in vitro against two Trypanosoma brucei (T.b.) subspecies: T.b. brucei and T.b. rhodesiense, Trypanosoma cruzi, Leishmania donovani and two Plasmodium falciparum subspecies: a chloroquine-sensitive str...

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Bibliographic Details
Main Authors: Jean J. Vanden Eynde, Annie Mayence, Madhusoodanan Mottamal, Cyrus J. Bacchi, Nigel Yarlett, Marcel Kaiser, Reto Brun, Tien L. Huang
Format: Article
Language:English
Published: MDPI AG 2016-04-01
Series:Pharmaceuticals
Subjects:
antiparasitics
bisbenzamidines
DNA binding
Plasmodium falciparum
Trypanosoma brucei
Online Access:http://www.mdpi.com/1424-8247/9/2/20

Internet

http://www.mdpi.com/1424-8247/9/2/20

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