Arc 3′ UTR Splicing Leads to Dual and Antagonistic Effects in Fine-Tuning Arc Expression Upon BDNF Signaling

Arc 3′ UTR Splicing Leads to Dual and Antagonistic Effects in Fine-Tuning Arc Expression Upon BDNF Signaling

Activity-regulated cytoskeletal associated protein (Arc) is an immediate-early gene critically involved in synaptic plasticity and memory consolidation. Arc mRNA is rapidly induced by synaptic activation and a portion is locally translated in dendrites where it modulates synaptic strength. Being an...

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Bibliographic Details
Main Authors: Chiara Paolantoni, Simona Ricciardi, Veronica De Paolis, Chinenye Okenwa, Caterina Catalanotto, Maria T. Ciotti, Antonino Cattaneo, Carlo Cogoni, Corinna Giorgi
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-04-01
Series:Frontiers in Molecular Neuroscience
Subjects:
Arc
EJC
splicing
BDNF
plasticity
post-transcriptional regulation
Online Access:http://journal.frontiersin.org/article/10.3389/fnmol.2018.00145/full

Internet

http://journal.frontiersin.org/article/10.3389/fnmol.2018.00145/full

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