Mebendazole, an anti-helminth drug, suppresses inflammation, oxidative stress and injury in a mouse model of ulcerative colitis

Mebendazole, an anti-helminth drug, suppresses inflammation, oxidative stress and injury in a mouse model of ulcerative colitis

Abstract Mebendazole (MBZ) is an efficacious anthelmintic with known anti-inflammatory and fibrinolytic properties. In this study, we aimed to explore the protective effects of this FDA-approved drug against DSS-induced colitis in a murine model either alone or in combination with Sulfasalazine (SSZ...

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Bibliographic Details
Main Authors: Moein Eskandari, Fereshteh Asgharzadeh, Mohammad Mostafa Askarnia-faal, Hamideh Naimi, Amir Avan, Mitra Ahadi, Hassan Vossoughinia, Masoumeh Gharib, Atena Soleimani, Niloufar Naghibzadeh, Gordon Ferns, Mikhail Ryzhikov, Majid Khazaei, Seyed Mahdi Hassanian
Format: Article
Language:English
Published: Nature Portfolio 2022-06-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-022-14420-6

Internet

https://doi.org/10.1038/s41598-022-14420-6

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