PheWAS and cross-disorder analysis reveal genetic architecture, pleiotropic loci and phenotypic correlations across 11 autoimmune disorders

PheWAS and cross-disorder analysis reveal genetic architecture, pleiotropic loci and phenotypic correlations across 11 autoimmune disorders

IntroductionAutoimmune disorders (ADs) are a group of about 80 disorders that occur when self-attacking autoantibodies are produced due to failure in the self-tolerance mechanisms. ADs are polygenic disorders and associations with genes both in the human leukocyte antigen (HLA) region and outside of...

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Main Authors: Apostolia Topaloudi, Pritesh Jain, Melanie B. Martinez, Josephine K. Bryant, Grace Reynolds, Zoi Zagoriti, George Lagoumintzis, Eleni Zamba-Papanicolaou, John Tzartos, Konstantinos Poulas, Kleopas A. Kleopa, Socrates Tzartos, Marianthi Georgitsi, Petros Drineas, Peristera Paschou
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-09-01
Series:Frontiers in Immunology
Subjects:
PheWAS
autoimmune disorders
cross-disorder
GWAS
meta-analysis
PRS
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1147573/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2023.1147573/full

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