Glomerular endothelial glycocalyx-derived heparan sulfate inhibits glomerular leukocyte influx and attenuates experimental glomerulonephritis

Glomerular endothelial glycocalyx-derived heparan sulfate inhibits glomerular leukocyte influx and attenuates experimental glomerulonephritis

Proliferative forms of glomerulonephritis are characterized by the influx of leukocytes, albuminuria, and loss of kidney function. The glomerular endothelial glycocalyx is a thick carbohydrate layer that covers the endothelium and is comprised of heparan sulfate (HS), which plays a pivotal role in g...

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Bibliographic Details
Main Authors: Marissa L. Maciej-Hulme, Jasper J. Van Gemst, Patience Sanderson, Angelique L. W. M. M. Rops, Jo H. Berden, Bart Smeets, I. Jonathan Amster, Ton J. Rabelink, Johan Van Der Vlag
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-06-01
Series:Frontiers in Molecular Biosciences
Subjects:
heparan sulfate
glomerulonephritis
leukocyte
glomerular endothelial cell
inflammation
glycocalyx
Online Access:https://www.frontiersin.org/articles/10.3389/fmolb.2023.1177560/full

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https://www.frontiersin.org/articles/10.3389/fmolb.2023.1177560/full

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