Tailor-made natural and synthetic grafts for precise urethral reconstruction
Abstract Injuries to the urethra can be caused by malformations, trauma, inflammation, or carcinoma, and reconstruction of the injured urethra is still a significant challenge in clinical urology. Implanting grafts for urethroplasty and end-to-end anastomosis are typical clinical interventions for u...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2022-08-01
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| Series: | Journal of Nanobiotechnology |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12951-022-01599-z |
| _version_ | 1811274875096006656 |
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| author | Qinyuan Tan Hanxiang Le Chao Tang Ming Zhang Weijie Yang Yazhao Hong Xiaoqing Wang |
| author_facet | Qinyuan Tan Hanxiang Le Chao Tang Ming Zhang Weijie Yang Yazhao Hong Xiaoqing Wang |
| author_sort | Qinyuan Tan |
| collection | DOAJ |
| description | Abstract Injuries to the urethra can be caused by malformations, trauma, inflammation, or carcinoma, and reconstruction of the injured urethra is still a significant challenge in clinical urology. Implanting grafts for urethroplasty and end-to-end anastomosis are typical clinical interventions for urethral injury. However, complications and high recurrence rates remain unsatisfactory. To address this, urethral tissue engineering provides a promising modality for urethral repair. Additionally, developing tailor-made biomimetic natural and synthetic grafts is of great significance for urethral reconstruction. In this work, tailor-made biomimetic natural and synthetic grafts are divided into scaffold-free and scaffolded grafts according to their structures, and the influence of different graft structures on urethral reconstruction is discussed. In addition, future development and potential clinical application strategies of future urethral reconstruction grafts are predicted. |
| first_indexed | 2024-04-12T23:26:55Z |
| format | Article |
| id | doaj.art-5066e01c9c4b442190a569caba54c182 |
| institution | Directory Open Access Journal |
| issn | 1477-3155 |
| language | English |
| last_indexed | 2024-04-12T23:26:55Z |
| publishDate | 2022-08-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Nanobiotechnology |
| spelling | doaj.art-5066e01c9c4b442190a569caba54c1822022-12-22T03:12:22ZengBMCJournal of Nanobiotechnology1477-31552022-08-0120112310.1186/s12951-022-01599-zTailor-made natural and synthetic grafts for precise urethral reconstructionQinyuan Tan0Hanxiang Le1Chao Tang2Ming Zhang3Weijie Yang4Yazhao Hong5Xiaoqing Wang6Department of Urology, The First Hospital of Jilin UniversityDepartment of Orthopedics, The Second Hospital of Jilin UniversityDepartment of Urology, The First Hospital of Jilin UniversityDepartment of Urology, The First Hospital of Jilin UniversityDepartment of Urology, The First Hospital of Jilin UniversityDepartment of Pediatric Surgery, The First Affiliated Hospital of Nanjing Medical UniversityDepartment of Urology, The First Hospital of Jilin UniversityAbstract Injuries to the urethra can be caused by malformations, trauma, inflammation, or carcinoma, and reconstruction of the injured urethra is still a significant challenge in clinical urology. Implanting grafts for urethroplasty and end-to-end anastomosis are typical clinical interventions for urethral injury. However, complications and high recurrence rates remain unsatisfactory. To address this, urethral tissue engineering provides a promising modality for urethral repair. Additionally, developing tailor-made biomimetic natural and synthetic grafts is of great significance for urethral reconstruction. In this work, tailor-made biomimetic natural and synthetic grafts are divided into scaffold-free and scaffolded grafts according to their structures, and the influence of different graft structures on urethral reconstruction is discussed. In addition, future development and potential clinical application strategies of future urethral reconstruction grafts are predicted.https://doi.org/10.1186/s12951-022-01599-zNatural graftSynthetic graftBiomimetic structureTissue engineeringPrecise urethral reconstruction |
| spellingShingle | Qinyuan Tan Hanxiang Le Chao Tang Ming Zhang Weijie Yang Yazhao Hong Xiaoqing Wang Tailor-made natural and synthetic grafts for precise urethral reconstruction Journal of Nanobiotechnology Natural graft Synthetic graft Biomimetic structure Tissue engineering Precise urethral reconstruction |
| title | Tailor-made natural and synthetic grafts for precise urethral reconstruction |
| title_full | Tailor-made natural and synthetic grafts for precise urethral reconstruction |
| title_fullStr | Tailor-made natural and synthetic grafts for precise urethral reconstruction |
| title_full_unstemmed | Tailor-made natural and synthetic grafts for precise urethral reconstruction |
| title_short | Tailor-made natural and synthetic grafts for precise urethral reconstruction |
| title_sort | tailor made natural and synthetic grafts for precise urethral reconstruction |
| topic | Natural graft Synthetic graft Biomimetic structure Tissue engineering Precise urethral reconstruction |
| url | https://doi.org/10.1186/s12951-022-01599-z |
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