Tyrosine 870 of TLR9 is critical for receptor maturation rather than phosphorylation-dependent ligand-induced signaling.

Tyrosine 870 of TLR9 is critical for receptor maturation rather than phosphorylation-dependent ligand-induced signaling.

Toll like receptors (TLRs) share a conserved structure comprising the N-terminal ectodomain, a transmembrane segment and a C-terminal cytoplasmic Toll/IL-1 receptor (TIR) domain. Proper assembly of the TIR domain is crucial for signal transduction; however, the contribution of individual motifs with...

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Bibliographic Details
Main Authors: Chhanda Biswas, Sheila Rao, Katharine Slade, David Hyman, Devin Dersh, Adriana R Mantegazza, Philip W Zoltick, Michael S Marks, Yair Argon, Edward M Behrens
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2018-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC6053202?pdf=render

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http://europepmc.org/articles/PMC6053202?pdf=render

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