Oncogenetic Function and Prognostic Value of DNA Topoisomerase II Alpha in Human Malignances: A Pan-Cancer Analysis
Increasing studies have revealed significant associations between TOP2A with oncogenesis and prognosis of human cancers; however, pan-cancer analysis has not been reported. Here, we explored the potential carcinogenic function and the association with clinical outcomes of TOP2A in 33 different human...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-07-01
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| Series: | Frontiers in Genetics |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fgene.2022.856692/full |
| _version_ | 1818113236457750528 |
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| author | Fulai Zhao Fulai Zhao Junli Chang Junli Chang Peng Zhao Peng Zhao Wenyi Wang Wenyi Wang Xingyuan Sun Xingyuan Sun Xiaoping Ma Xiaoping Ma Mengchen Yin Yongjun Wang Yongjun Wang Yanping Yang Yanping Yang |
| author_facet | Fulai Zhao Fulai Zhao Junli Chang Junli Chang Peng Zhao Peng Zhao Wenyi Wang Wenyi Wang Xingyuan Sun Xingyuan Sun Xiaoping Ma Xiaoping Ma Mengchen Yin Yongjun Wang Yongjun Wang Yanping Yang Yanping Yang |
| author_sort | Fulai Zhao |
| collection | DOAJ |
| description | Increasing studies have revealed significant associations between TOP2A with oncogenesis and prognosis of human cancers; however, pan-cancer analysis has not been reported. Here, we explored the potential carcinogenic function and the association with clinical outcomes of TOP2A in 33 different human cancers. The results showed that TOP2A was amplified in 31 investigated cancers; TOP2A expression was significantly associated with metastasis of six different cancers and significantly associated with the survival of patients in ten different cancers; TOP2A-encoded protein was obviously upregulated in five available cancers; phosphorylated TOP2A protein at S1106 was significantly upregulated in all six available cancers. Moreover, TOP2A expression was found to be associated with the cancer-associated immune cell infiltration, including fibroblasts, Tregs, and macrophages. In addition, the Kyoto encyclopedia of genes and genomes (KEGG) pathway and Gene Ontology (GO) enrichment analyses revealed a most significant association between TOP2A with the Wnt signaling pathway and DNA conformation change. This work provides a comprehensive knowledge of TOP2A in different cancers, including carcinogenic function, prognostic values for metastasis, and clinical outcomes. |
| first_indexed | 2024-12-11T03:31:37Z |
| format | Article |
| id | doaj.art-50692ddde34e4c5d9f91d2a23240b6cf |
| institution | Directory Open Access Journal |
| issn | 1664-8021 |
| language | English |
| last_indexed | 2024-12-11T03:31:37Z |
| publishDate | 2022-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Genetics |
| spelling | doaj.art-50692ddde34e4c5d9f91d2a23240b6cf2022-12-22T01:22:22ZengFrontiers Media S.A.Frontiers in Genetics1664-80212022-07-011310.3389/fgene.2022.856692856692Oncogenetic Function and Prognostic Value of DNA Topoisomerase II Alpha in Human Malignances: A Pan-Cancer AnalysisFulai Zhao0Fulai Zhao1Junli Chang2Junli Chang3Peng Zhao4Peng Zhao5Wenyi Wang6Wenyi Wang7Xingyuan Sun8Xingyuan Sun9Xiaoping Ma10Xiaoping Ma11Mengchen Yin12Yongjun Wang13Yongjun Wang14Yanping Yang15Yanping Yang16Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, ChinaKey Laboratory of Theory and Therapy of Muscles and Bones, Ministry of Education, Shanghai, ChinaLonghua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, ChinaKey Laboratory of Theory and Therapy of Muscles and Bones, Ministry of Education, Shanghai, ChinaLonghua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, ChinaKey Laboratory of Theory and Therapy of Muscles and Bones, Ministry of Education, Shanghai, ChinaLonghua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, ChinaKey Laboratory of Theory and Therapy of Muscles and Bones, Ministry of Education, Shanghai, ChinaLonghua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, ChinaKey Laboratory of Theory and Therapy of Muscles and Bones, Ministry of Education, Shanghai, ChinaLonghua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, ChinaKey Laboratory of Theory and Therapy of Muscles and Bones, Ministry of Education, Shanghai, ChinaLonghua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, ChinaLonghua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, ChinaKey Laboratory of Theory and Therapy of Muscles and Bones, Ministry of Education, Shanghai, ChinaLonghua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, ChinaKey Laboratory of Theory and Therapy of Muscles and Bones, Ministry of Education, Shanghai, ChinaIncreasing studies have revealed significant associations between TOP2A with oncogenesis and prognosis of human cancers; however, pan-cancer analysis has not been reported. Here, we explored the potential carcinogenic function and the association with clinical outcomes of TOP2A in 33 different human cancers. The results showed that TOP2A was amplified in 31 investigated cancers; TOP2A expression was significantly associated with metastasis of six different cancers and significantly associated with the survival of patients in ten different cancers; TOP2A-encoded protein was obviously upregulated in five available cancers; phosphorylated TOP2A protein at S1106 was significantly upregulated in all six available cancers. Moreover, TOP2A expression was found to be associated with the cancer-associated immune cell infiltration, including fibroblasts, Tregs, and macrophages. In addition, the Kyoto encyclopedia of genes and genomes (KEGG) pathway and Gene Ontology (GO) enrichment analyses revealed a most significant association between TOP2A with the Wnt signaling pathway and DNA conformation change. This work provides a comprehensive knowledge of TOP2A in different cancers, including carcinogenic function, prognostic values for metastasis, and clinical outcomes.https://www.frontiersin.org/articles/10.3389/fgene.2022.856692/fullDNA topoisomerase II alphapan-cancer analysisoncogenesisimmune cell infiltrationgenetic alterationprognostic value |
| spellingShingle | Fulai Zhao Fulai Zhao Junli Chang Junli Chang Peng Zhao Peng Zhao Wenyi Wang Wenyi Wang Xingyuan Sun Xingyuan Sun Xiaoping Ma Xiaoping Ma Mengchen Yin Yongjun Wang Yongjun Wang Yanping Yang Yanping Yang Oncogenetic Function and Prognostic Value of DNA Topoisomerase II Alpha in Human Malignances: A Pan-Cancer Analysis Frontiers in Genetics DNA topoisomerase II alpha pan-cancer analysis oncogenesis immune cell infiltration genetic alteration prognostic value |
| title | Oncogenetic Function and Prognostic Value of DNA Topoisomerase II Alpha in Human Malignances: A Pan-Cancer Analysis |
| title_full | Oncogenetic Function and Prognostic Value of DNA Topoisomerase II Alpha in Human Malignances: A Pan-Cancer Analysis |
| title_fullStr | Oncogenetic Function and Prognostic Value of DNA Topoisomerase II Alpha in Human Malignances: A Pan-Cancer Analysis |
| title_full_unstemmed | Oncogenetic Function and Prognostic Value of DNA Topoisomerase II Alpha in Human Malignances: A Pan-Cancer Analysis |
| title_short | Oncogenetic Function and Prognostic Value of DNA Topoisomerase II Alpha in Human Malignances: A Pan-Cancer Analysis |
| title_sort | oncogenetic function and prognostic value of dna topoisomerase ii alpha in human malignances a pan cancer analysis |
| topic | DNA topoisomerase II alpha pan-cancer analysis oncogenesis immune cell infiltration genetic alteration prognostic value |
| url | https://www.frontiersin.org/articles/10.3389/fgene.2022.856692/full |
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