An Engineered IFNγ-Antibody Fusion Protein with Improved Tumor-Homing Properties

An Engineered IFNγ-Antibody Fusion Protein with Improved Tumor-Homing Properties

Interferon-gamma (IFNγ) is one of the central cytokines produced by the innate and adaptive immune systems. IFNγ directly favors tumor growth control by enhancing the immunogenicity of tumor cells, induces IP-10 secretion facilitating (CXCR3+) immune cell infiltration, and can prime macrophages to a...

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Bibliographic Details
Main Authors: Cesare Di Nitto, Ettore Gilardoni, Jacqueline Mock, Lisa Nadal, Tobias Weiss, Michael Weller, Frauke Seehusen, Chiara Libbra, Emanuele Puca, Dario Neri, Roberto De Luca
Format: Article
Language:English
Published: MDPI AG 2023-01-01
Series:Pharmaceutics
Subjects:
interferon-gamma
antibody fusion proteins
protein engineering
cytokines
immunotherapy
Online Access:https://www.mdpi.com/1999-4923/15/2/377

Internet

https://www.mdpi.com/1999-4923/15/2/377

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