In Vitro and Ex Vivo Synergistic Effect of Pyrvinium Pamoate Combined with Miltefosine and Paromomycin against <i>Leishmania</i>

In Vitro and Ex Vivo Synergistic Effect of Pyrvinium Pamoate Combined with Miltefosine and Paromomycin against <i>Leishmania</i>

One of the major drawbacks of current treatments for neglected tropical diseases is the low safety of the drugs used and the emergence of resistance. Leishmaniasis is a group of neglected diseases caused by protozoa of the trypanosomatidae family that lacks preventive vaccines and whose pharmacologi...

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Bibliographic Details
Main Authors: Estela Melcón-Fernández, Giulio Galli, Rafael Balaña-Fouce, Nerea García-Fernández, María Martínez-Valladares, Rosa M. Reguera, Carlos García-Estrada, Yolanda Pérez-Pertejo
Format: Article
Language:English
Published: MDPI AG 2024-01-01
Series:Tropical Medicine and Infectious Disease
Subjects:
Leishmania
drug repurposing
drug combinations
pyrvinium pamoate plus miltefosine
pyrvinium pamoate plus paromomycin
intestinal organoids
Online Access:https://www.mdpi.com/2414-6366/9/2/30

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https://www.mdpi.com/2414-6366/9/2/30

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