Accumulation of copy number alterations and clinical progression across advanced prostate cancer

Accumulation of copy number alterations and clinical progression across advanced prostate cancer

Abstract Background Genomic copy number alterations commonly occur in prostate cancer and are one measure of genomic instability. The clinical implication of copy number change in advanced prostate cancer, which defines a wide spectrum of disease from high-risk localised to metastatic, is unknown. M...

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Main Authors: Emily Grist, Stefanie Friedrich, Christopher Brawley, Larissa Mendes, Marina Parry, Adnan Ali, Aine Haran, Alex Hoyle, Claire Gilson, Sharanpreet Lall, Leila Zakka, Carla Bautista, Alex Landless, Karolina Nowakowska, Anna Wingate, Daniel Wetterskog, A. M. Mahedi Hasan, Nafisah B. Akato, Malissa Richmond, Sofeya Ishaq, Nik Matthews, Anis A. Hamid, Christopher J. Sweeney, Matthew R. Sydes, Daniel M. Berney, Stefano Lise, STAMPEDE investigators, Mahesh K. B. Parmar, Noel W. Clarke, Nicholas D. James, Paolo Cremaschi, Louise C. Brown, Gerhardt Attard
Format: Article
Language:English
Published: BMC 2022-09-01
Series:Genome Medicine
Subjects:
Advanced prostate cancer
Genomic biomarkers
Copy number alteration
STAMPEDE trial
Online Access:https://doi.org/10.1186/s13073-022-01080-4

Internet

https://doi.org/10.1186/s13073-022-01080-4

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