Octyl Gallate Induces Pancreatic Ductal Adenocarcinoma Cell Apoptosis and Suppresses Endothelial-Mesenchymal Transition-Promoted M2-Macrophages, HSP90α Secretion, and Tumor Growth

Octyl Gallate Induces Pancreatic Ductal Adenocarcinoma Cell Apoptosis and Suppresses Endothelial-Mesenchymal Transition-Promoted M2-Macrophages, HSP90α Secretion, and Tumor Growth

Octyl gallate (OG) is a common antioxidant and preservative safely used in food additive and cosmetics. In this study, OG exhibited an activity to induce apoptosis in pancreatic ductal adenocarcinoma (PDAC) cells. It induced BNIP3L level and facilitated physical associations of BNIP3L with Bcl-2 as...

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Bibliographic Details
Main Authors: Kee Voon Chua, Chi-Shuan Fan, Chia-Chi Chen, Li-Li Chen, Shu-Chen Hsieh, Tze-Sing Huang
Format: Article
Language:English
Published: MDPI AG 2019-12-01
Series:Cells
Subjects:
octyl gallate
endothelial-to-mesenchymal transition
cancer-associated fibroblasts
myeloid-derived macrophages
extracellular hsp90α
Online Access:https://www.mdpi.com/2073-4409/9/1/91

Internet

https://www.mdpi.com/2073-4409/9/1/91

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