Application of Photodynamic Therapy with 5-Aminolevulinic Acid to Extracorporeal Photopheresis in the Treatment of Patients with Chronic Graft-versus-Host Disease: A First-in-Human Study

Application of Photodynamic Therapy with 5-Aminolevulinic Acid to Extracorporeal Photopheresis in the Treatment of Patients with Chronic Graft-versus-Host Disease: A First-in-Human Study

Extracorporeal photopheresis (ECP), an immunomodulatory therapy for the treatment of chronic graft-versus-host disease (cGvHD), exposes isolated white blood cells to photoactivatable 8-methoxypsoralen (8-MOP) and UVA light to induce the apoptosis of T-cells and, hence, to modulate immune responses....

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Bibliographic Details
Main Authors: Eidi Christensen, Olav A. Foss, Petter Quist-Paulsen, Ingrid Staur, Frode Pettersen, Toril Holien, Petras Juzenas, Qian Peng
Format: Article
Language:English
Published: MDPI AG 2021-09-01
Series:Pharmaceutics
Subjects:
5-aminolevulinic acid
ALA-based photodynamic therapy
phototherapy
extracorporeal
photopheresis
chronic graft-versus-host disease
Online Access:https://www.mdpi.com/1999-4923/13/10/1558

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https://www.mdpi.com/1999-4923/13/10/1558

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