The anti-hypercholesterolemic effect of low p53 expression protects vascular endothelial function in mice.
To demonstrate that p53 modulates endothelial function and the stress response to a high-fat western diet (WD).Three-month old p53+/+ wild type (WT) and p53+/- male mice were fed a regular or WD for 3 months. Plasma levels of total cholesterol (TC) and LDL-cholesterol were significantly elevated (p&...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2014-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC3960235?pdf=render |