The anti-hypercholesterolemic effect of low p53 expression protects vascular endothelial function in mice.

The anti-hypercholesterolemic effect of low p53 expression protects vascular endothelial function in mice.

To demonstrate that p53 modulates endothelial function and the stress response to a high-fat western diet (WD).Three-month old p53+/+ wild type (WT) and p53+/- male mice were fed a regular or WD for 3 months. Plasma levels of total cholesterol (TC) and LDL-cholesterol were significantly elevated (p&...

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Bibliographic Details
Main Authors: Francois Leblond, Steve Poirier, Carol Yu, Natacha Duquette, Gaetan Mayer, Eric Thorin
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3960235?pdf=render

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