Phox2b mutation mediated by Atoh1 expression impaired respiratory rhythm and ventilatory responses to hypoxia and hypercapnia

Phox2b mutation mediated by Atoh1 expression impaired respiratory rhythm and ventilatory responses to hypoxia and hypercapnia

Mutations in the transcription factor Phox2b cause congenital central hypoventilation syndrome (CCHS). The syndrome is characterized by hypoventilation and inability to regulate breathing to maintain adequate O2 and CO2 levels. The mechanism by which CCHS impact respiratory control is incompletely u...

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Bibliographic Details
Main Authors: Caroline B Ferreira, Talita M Silva, Phelipe E Silva, Claudio L Castro, Catherine Czeisler, José J Otero, Ana C Takakura, Thiago S Moreira
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2022-11-01
Series:eLife
Subjects:
hypercapnia
hypoxia
ventilation
phox2b
retrotrapezoid nucleus
Online Access:https://elifesciences.org/articles/73130

Internet

https://elifesciences.org/articles/73130

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