Fatigue as hallmark of Fabry disease: role of bioenergetic alterations

Fatigue as hallmark of Fabry disease: role of bioenergetic alterations

Fabry disease (FD) is a lysosomal storage disorder due to the impaired activity of the α-galactosidase A (GLA) enzyme which induces Gb3 deposition and multiorgan dysfunction. Exercise intolerance and fatigue are frequent and early findings in FD patients, representing a self-standing clinical phenot...

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Bibliographic Details
Main Authors: Jessica Gambardella, Eleonora Riccio, Antonio Bianco, Antonella Fiordelisi, Federica Andrea Cerasuolo, Antonietta Buonaiuto, Teodolinda Di Risi, Alessandro Viti, Roberta Avvisato, Antonio Pisani, Daniela Sorriento, Guido Iaccarino
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-01-01
Series:Frontiers in Cardiovascular Medicine
Subjects:
Fabry
metabolism
fatigue
skeletal muscle
exercise intolerance
Online Access:https://www.frontiersin.org/articles/10.3389/fcvm.2024.1341590/full

Internet

https://www.frontiersin.org/articles/10.3389/fcvm.2024.1341590/full

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